suppressor mutation การใช้

• Another possibility for mutation correction is the use of a suppressor mutation.
• Suppressor mutations also occur in genes that code for virus structural proteins.
• In addition to the reading frame, Crick also used suppressor mutations to determine codon size.
• Suppressor mutations are extremely useful to define the functions of biochemical pathways within a cell and the relationships between different biochemical pathways.
• Suppressor mutations can be described as second mutations at a site on the chromosome distinct from the mutation under study, which suppress the phenotype of the original mutation.
• A "'suppressor screen "'is used to identify suppressor mutations which alleviate or revert the phenotype of the original mutation, in a process defined as synthetic viability.
• For most genes, the phenotype of the heterozygous suppressor mutation by itself would be wild type ( because most genes are not haplo-insufficient ), so that the double mutant ( suppressed ) phenotype is intermediate between those of the single mutants.
• "' Alan Garen "'is geneticist, who co-discovered suppressor mutations for tRNA . The Garen lab also showed that certain triplet codons ( 5'- UAG, 5'- UAA, and 5'- UGA ) failed to bind amino acids.